WATCH: Uptown Funk' wins Record of the Year Grammy

"Uptown Funk" beat out other chart-topping tracks including Ed Sheeran's "Thinking Out Loud" and Taylor Swift's "Blank Space" to win the award, one of the most prestigious Grammys which recognizes songs including their performers.

Ronson, a longtime producer from Britain who has notably worked with superstar Adele, found unprecedented success in his own right with "Uptown Funk," with its instantly catchy lines "Girls hit your hallelujah" and "Uptown funk you up."

Featuring vocals by Mars, the song has the feel both musically and lyrically of the funky dance pop Minneapolis Sound popularized in the 1980s by Prince and quickly became a favorite both of dance clubs and of advertisers.

"Uptown Funk" spent 14 weeks at number one on the Billboard singles chart in the United States, tying for second place on the all-time list. The song is also the fourth most streamed ever on Spotify.

Ronson and Mars won loud applause a week ago when they played the song at the halftime show of the Super Bowl, the most widely watched US broadcast of the year, where they joined Coldplay and Beyonce.

The song also topped the charts in a number of other countries and won the Brit Award for British Single of the Year.

The Record of the Year goes to Ronson and Mars as well as producers including Jeff Bhasker, a fixture on the Los Angeles music scene who has worked with Kanye West, Swift and Beyonce among other stars.